Non-refoldability in E. coli Proteome

This lecture by the instructor explores the concept of non-refoldability in the E. coli proteome, highlighting the challenges and implications of protein folding. Through a detailed analysis of protein folding kinetics, domain composition, and refolding experiments, the lecture sheds light on the factors influencing protein refoldability. The presentation also delves into the role of co-translational folding and the impact of subunit composition on protein refolding efficiency.