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This lecture by the instructor covers the basic concepts and translational opportunities in immunometabolism, focusing on the interactions of innate lymphocytes with different cell types, the innate regulation of adaptive immune responses, and the adaptive regulation of innate lymphocyte responses. The complexity of the immune system, the role of metabolism beyond energy production, and the impact of metabolism on immune cell function are discussed. The lecture also delves into the Warburg effect, the role of mitochondria as the energy powerhouse, and the influence of metabolic pathways on cellular functions.