Platinum Drugs for Cancer: Mechanisms and Variants

This lecture explores the importance of organic chemistry, focusing on platinum-based drugs for cancer treatment. It covers the working mechanisms of these drugs, their severe side effects, and the development of improved versions worldwide. Additionally, it delves into the concept of electrophilic aromatic substitution, discussing key reactions and important examples. The lecture also touches upon the cross-coupling of aromatic compounds using palladium catalysis, highlighting the ongoing research to replace palladium with more cost-effective and less toxic metals. Furthermore, it presents the synthesis of Rucaparib, a Pfizer drug for ovarian cancer, through aromatic compound cross-coupling. The lecture concludes with a detailed analysis of the factors influencing SN2 and SN1 reactions in organic chemistry.