This lecture covers the sources of noise and interference in data acquisition systems, including thermal noise, shot noise, and amplifier noise. It explains the physics behind thermal noise and the fluctuation-dissipation theorem. The lecture also discusses the role of preamplifiers, quantifying noise with SNR and noise figure, and noise temperature. Examples of noise calculations for electronic amplifiers and photodiodes are presented, along with the effects of ADC noise such as aliasing and quantization error.