This lecture delves into the importance of calculating extracellular potentials in simulating a hippocampus microcircuit. It explores how this calculation enhances signal interpretation, enables simultaneous measurement of various activities, and aids in understanding underlying neural patterns. The method's utility in dissecting signals across different compartments and times is discussed, along with strategies for validation and electrode placement. The instructor provides insights on leveraging extracellular potentials to improve measurements and gain a comprehensive view of neural activities.