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This lecture covers the concept of bistability in the cell cycle, focusing on positive feedback mechanisms and the transformation of smooth inputs into abrupt responses. It delves into the biochemical aspects of bistable systems, fixed points, stability, and hysteresis. The instructor explains the dynamics of bistability through the analysis of vector fields, phase portraits, and stability classifications. The lecture also discusses the role of CDK, WEE1, and other key components in creating bistable responses in the cell cycle.