This lecture discusses the Cyber Physical System Challenge for Model Based Design, focusing on the co-design process between physical and computational processes. It covers the goals, challenges, and structure of a large DARPA-funded project aiming to create an end-to-end model and component-based design flow for new generation amphibious vehicles. The lecture explores the development of a model library, the concept of democratizing design, and the integration of open-source tools. It also delves into the information architecture, design flow, and semantic integration challenges faced in the project, emphasizing the importance of science and theory in solving engineering problems.