Pharmacokinetics: Drug Absorption and Distribution

This lecture covers the science of drug action on biological systems, focusing on drug absorption and distribution in the body. It discusses the identification of biological targets, drug development, drug safety, and the impact of drug toxicities. The course delves into the mechanisms of drug absorption, distribution, metabolism, and excretion, as well as the factors affecting enteral drug absorption. It also explores the concepts of bioavailability, carrier-mediated transport, and the effects of drug ionization on transmembrane diffusion. Additionally, the lecture touches on the clinical implications of drug absorption, such as salicylate poisoning and the role of lysosomes in drug trapping.