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This lecture explores the evolution of transistors over the last 40 years, focusing on the impact of quantum mechanical effects on nano-devices. The instructor discusses the need for advanced TCAD tools based on quantum concepts to accurately model and predict the performance of modern transistors. The presentation covers the challenges and opportunities in TCAD research, introducing an in-house tool and showcasing its applications. Topics include the limitations of MOSFET performance, the future of Moore's scaling law, and the functionality of memristors in comparison to the human brain's efficiency.