Pro-tumoral Inflammation: De Palma

This lecture discusses the role of inflammation in promoting tumor growth and progression, focusing on the mechanisms by which inflammatory cells such as neutrophils and myeloid-derived suppressor cells (MDSCs) contribute to immunosuppression in the tumor microenvironment. It covers the production of reactive oxygen species (ROS) by inflammatory cells to kill pathogens, the expansion of MDSCs during tumor growth, and the involvement of STAT3 in promoting MDSC expansion. Furthermore, it explores how MDSCs induce immunosuppression through the depletion of arginine and the production of ROS and peroxynitrite. The lecture also delves into the interactions between cancer cells and inflammatory cells, highlighting the impact of tumor-associated macrophages (TAMs) on tumor growth, angiogenesis, invasion, and metastasis.