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This lecture explores the impact of environmental factors on public health through the case study of Madame Favre, a diabetic patient. It discusses the influence of genetic factors, living conditions, and healthcare on health outcomes, emphasizing the importance of a systemic approach. The lecture delves into the intricate links between health, environment, and climate change, highlighting the challenges posed by deforestation and zoonotic diseases. It also examines the relationship between human activities, climate change, and various health issues, such as respiratory diseases and mental health impacts. Furthermore, it addresses the connections between climate variability, pathogens distribution, and disease incidence, shedding light on the complex interplay between climate and public health.