Circadian and Cell Cycle Dynamics: Coupling and Synchronization

This lecture explores the synchronization and coupling of circadian and cell cycles in mammalian cells, focusing on the impact of cell divisions on the circadian period and the absence of gating in 3T3 cells. The instructor discusses the dynamics of two coupled oscillators, the reconstruction of noisy phase dynamics, and the prediction of stable attractors. The lecture also covers the connection between theory and data, including generative models and optimization. Moreover, it delves into the identification of dynamics from data and the influence of cell proliferation on organ-specific time. The presentation concludes by addressing the potential for identifying brain/neuronal states dynamics from data.