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This lecture covers the application of differential amplifiers in electrocardiogram (ECG) signal processing, focusing on the design considerations and challenges related to amplifying ECG signals while rejecting common mode interference. The instructor explains the importance of differential measurements, the impact of imperfections in differential amplifiers, and the use of operational amplifiers to achieve high input impedance. Various circuit configurations and their effects on signal amplification and rejection are discussed, emphasizing the need for precise component matching. The lecture concludes with a detailed analysis of common mode rejection techniques, including the right-leg drive method.