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This lecture compares the cellular structures of eukaryotes and prokaryotes, focusing on the differences in organelles, membranes, and genetic characteristics. It discusses the unique features of eukaryotes, such as membrane-bound organelles and linear chromosomes, contrasting them with prokaryotes' circular chromosomes. The lecture also covers gene expression, lipid biology, protein trafficking, and DNA replication. It explores the endosymbiotic theory of mitochondria and chloroplasts, as well as the horizontal transfer of genetic information in evolution.