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This lecture explores the applications of accelerators in society, from advanced instruments for science to medical diagnostics and treatment. It delves into the role of accelerators in physical and life sciences, showcasing how instruments drive theoretical understanding. The lecture also covers the spread of proton therapy technologies and the intelligence of accelerator-based instruments in studying mouse brain microvascular architecture. Additionally, it discusses the need for upgrades in accelerator-based instruments and ongoing research in high-field magnets. The session concludes with a reflection on the significance of astronomy in various fields, as depicted in philosophical dialogues. Throughout history, particle accelerators have been engines of discovery, shaping our understanding of the universe.