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This lecture introduces the importance of a global and interdisciplinary perspective in addressing health challenges. It covers the dimensions of poly-perspective, creativity, and citizenship in engineering and science. The lecture emphasizes the need for ethical standards, cultural sensitivity, and social responsibility in technological advancements. It discusses the impact of global issues on health, including demographic trends, migration, urbanization, and development inequalities. The session also explores mental health as a critical global issue, highlighting the social, biological, and environmental factors influencing mental well-being. Additionally, it delves into the governance of global health, technological advancements in biomedicine, and the societal implications of post-genomics. The lecture concludes with a focus on the health impact of demographic changes, development inequalities, and the major causes of mortality worldwide.