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This lecture covers the operation and applications of Superconducting Quantum Interference Devices (SQUIDs). It explains how SQUIDs work based on the quantization of magnetic flux and the Josephson effect. The lecture details the sensitivity of SQUIDs to magnetic fields, the critical current, and the voltage variations across the loop. It also discusses the extraordinary resolution of SQUID magnetometers, their measuring range, and examples of their applications in detecting weak magnetic fields in various fields such as neuroscience, material science, and food inspection.