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This lecture covers the advantages and disadvantages of liquid-fuel reactors over solid-fuel reactors, focusing on molten salt reactors (MSRs). It discusses the different types of MSR fuel options, technological advantages, neutron properties of fluoride salt melts, and the schemes of MSR projects like the Fuji MSR project. The lecture also explores the potential of thorium in MSRs, safety aspects, and the thorium cycle. It concludes with a comparison of fissile nuclides for the thorium-uranium cycle startup and the radiotoxicity in final repositories.