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This lecture delves into the intricate world of synaptic connectivity within the hippocampal regions, exploring the experimental validation of motif spatial embedding and the impact of morphology on cortical cell types. Through techniques like multi-patch clamp recordings and mGRASP, the instructor showcases the complexity of neuronal networks and the challenges in reconstructing connectivity at multiple scales. The lecture also highlights the significance of modeling approaches in understanding the connectome's complexity and the interplay between experiments and models.