Nuclear Medicine: Radioactive Tracers in Medical Imaging

Description

This lecture discusses the use of radioactive tracers in medical imaging, focusing on the example of thallium-201 for myocardial scintigraphy. It covers the nuclear reactions involved in producing thallium-201, the calculation of initial nuclei and corresponding mass, toxicity assessment, and the concept of half-life. Additionally, it explores the development of a technique for dating wines using cesium-137, a product of nuclear fission. The lecture explains the principles of fission reactions, isotopes, and the detection of cesium-137 in wines to determine their vintage. It also delves into the decay process, energy release, and the application of radioactive decay in authenticating wines.

Official source

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Isotopic labeling

Isotopic labeling (or isotopic labelling) is a technique used to track the passage of an isotope (an atom with a detectable variation in neutron count) through a reaction, metabolic pathway, or cell. The reactant is 'labeled' by replacing specific atoms by their isotope. The reactant is then allowed to undergo the reaction. The position of the isotopes in the products is measured to determine the sequence the isotopic atom followed in the reaction or the cell's metabolic pathway.

Nuclear fission

Nuclear fission is a reaction in which the nucleus of an atom splits into two or more smaller nuclei. The fission process often produces gamma photons, and releases a very large amount of energy even by the energetic standards of radioactive decay. Nuclear fission was discovered on 19 December 1938 in Berlin by German chemists Otto Hahn and Fritz Strassmann. Physicists Lise Meitner and her nephew Otto Robert Frisch explained it theoretically in January 1939. Frisch named the process "fission" by analogy with biological fission of living cells.

Decay chain

In nuclear science, the decay chain refers to a series of radioactive decays of different radioactive decay products as a sequential series of transformations. It is also known as a "radioactive cascade". The typical radioisotope does not decay directly to a stable state, but rather it decays to another radioisotope. Thus there is usually a series of decays until the atom has become a stable isotope, meaning that the nucleus of the atom has reached a stable state. Decay stages are referred to by their relationship to previous or subsequent stages.

Isotope

Isotopes are distinct nuclear species (or nuclides, as technical term) of the same element. They have the same atomic number (number of protons in their nuclei) and position in the periodic table (and hence belong to the same chemical element), but differ in nucleon numbers (mass numbers) due to different numbers of neutrons in their nuclei. While all isotopes of a given element have almost the same chemical properties, they have different atomic masses and physical properties.

Medical imaging

Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities.