Nuclear Receptors: Coactivators and Transcriptional Modulation

This lecture delves into the role of coactivators in modulating transcriptional activity by loosening histone complexes from DNA, exposing additional regions for transcription machinery. It explains histone acetylation, the structure of bromodomains, and the activation of transcription. The lecture also covers ERa antagonists, the membrane ER signaling pathway, tissue-specific actions of selective estrogen receptor modulators, and tissue-specific nuclear receptor signaling.