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This lecture covers the medical context of plasma medicine, focusing on head and neck cancer and foot ulcers in diabetic patients. It then delves into the origins and development of plasma medicine, highlighting its multidisciplinary nature and the emergence of this research field. The basics of cold plasma science and technology are explained, including the states of matter, characteristics of cold plasma, and various plasma sources for treating living systems. Different approaches, such as direct and indirect contact methods, are discussed, emphasizing the therapeutic potential of cold atmospheric plasma. The lecture concludes by exploring the innovative applications of cold atmospheric plasma in treating diseases where conventional therapies have limitations.