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This lecture covers the use of polymers, hydrogels, and particles in biomaterials applications. It starts with an introduction to biomaterials, followed by discussions on naturally derived and manmade biomaterials. The focus then shifts to polymers, nanoparticles, and their specific applications in drug delivery, cell adhesion, immune engineering, and tissue engineering. The lecture also addresses measurements, regulations, and translation of biomaterials. Topics include polymer coatings, dendrimers, PEGylation, hydrogels, drug-network interactions, and stimuli-responsive polymers.