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This lecture discusses the ethical implications of CRISPR gene editing technology on human embryos, focusing on the outrage within the scientific community due to the announcement of gene-edited babies. The speaker explores the potential permanent changes to human existence through genome editing and the case of Hu Jiankui's controversial gene experiment. Additionally, the lecture delves into the Darwinistic frustration of altering the human genome using CRISPR/Cas technology and the development of autologous gene editing in onco immunology, particularly in cancer treatment. The importance of scientific integrity in research is emphasized through an oath taken at a PhD defense.