Hydrogels as Biomaterials

This lecture explores the definition, key properties, synthesis schemes, and structural considerations of hydrogels, emphasizing their applications as biomaterials. The instructor discusses the classification of hydrogels based on crosslinking mechanisms and polymer origin. Key properties such as in situ formability, tissue-like transport, mechanical properties, degradability, responsiveness, and engineerability are highlighted. Various chemical crosslinking schemes and synthesis methods for hydrogels are presented, including physically crosslinked hydrogels. The lecture delves into the importance of network parameters, swelling thermodynamics, and selected applications of hydrogels in drug delivery, tissue engineering, and cell biology, showcasing examples of glucose-responsive gels and drug delivery systems. Challenges in hydrogel design and solutions involving pore creation, matrix degradation, and reversible bonds are also discussed.