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This lecture covers the influence of self-diffusion on the MR signal in biomedical imaging, explaining concepts such as the self-diffusion coefficient, root mean square displacement, and the effect of random motion on magnetization phase. It also delves into the mathematical description of how diffusion affects the MR signal, including factors like the strength of the diffusion process, delay between dephasing and rephasing gradients, and the area of the dephasing gradient.