Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
This lecture explores the direct-coupling analysis of residue coevolution in protein families, aiming to capture native contacts. It covers the methodology, including input data, evolutionary constraints, and the disentanglement of direct and indirect correlations. The lecture also discusses the performance of the analysis in predicting spatial proximity and protein interactions.