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This lecture introduces the emerging field of immunoengineering, focusing on the application of engineering principles to manipulate the immune system. It covers the interactions between engineering and immunology, the development of genetically engineered immune cells for cancer therapy, and key technologies in immunological analysis. The lecture also discusses the use of monoclonal antibodies, flow cytometry, and mass cytometry to study immune cells. Furthermore, it explores the clonal immune system, the identification of antigen-specific T-cells, and the role of mechanical force in the immune system. Various techniques for characterizing the mechanical force of cells are presented, including cytoindentation, atomic force microscopy, and microplate stretcher.