This lecture covers the fundamentals of tracer kinetics in biomedical imaging, focusing on the one-tissue compartment model. It explains first-order tracer kinetics, the unidirectional chemical reaction from S to T, and the measurement of tracer enrichment. The lecture also delves into the linear first-order ordinary differential equations describing the model and the Laplace transformation. Examples are provided to illustrate the concepts, including the input function, intravenous bolus infusion, and the concentration of authentic tracer in arterial blood over time.