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This lecture by the instructor delves into the importance of studying human neuronal microcircuits, exploring topics such as neuronal morphology, physiological properties of human neurons, and information transfer within neuronal microcircuits. The lecture also discusses the correlation between brain size and cognitive abilities, the molecular evolution of synapses, and the unique features of neocortical neurons in primates. Furthermore, it touches upon the evolution of cortical microcircuits and the modeling and simulation of human microcircuits. The presentation concludes with a reflection on the necessity of using data from mouse circuits for human microcircuit modeling.