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This lecture by the instructor covers the vapor phase processed plastics, focusing on Parylenes as insulating thermoplastics with high chemical inertness. It discusses the conformal coating properties, types, and mechanical properties of Parylene. Additionally, it explores the application of thin metal film sensors on polymer substrates, important materials like polyimide and metals, and the mechanical properties of the nervous system. The lecture delves into brain folding, cortex curvature across species, and the elasticity of neurons. It also touches on brain micromotion, the peripheral nervous system, and the mechanical properties of nerves. Finally, it presents metrics for design, neural signals recorded from the brain, and examples of clinical and research interfaces for the brain.