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This lecture provides an overview of vaccines, covering topics such as precision tumor recognition by T cells with combinatorial antigen-sensing circuits, challenges in adoptive T cell therapy, and the impact of vaccination on human health. It discusses the history of immunology and vaccines, the types of vaccines, and examples of current approved vaccines. The lecture also delves into the immune response, adaptive immunity, and the physiology of the primary immune response. Furthermore, it explores the different types of SARS-CoV-2 vaccines for COVID-19, including inactivated, attenuated, protein, and genetic vaccines.