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This lecture presents the IRSense project, an integrated sensing platform for gases and liquids in the threat range. The project involves a consortium of research groups from ETH, EPFL, the University of Neuchâtel, and the Farhochschule, Northwest Switzerland. The lecture explains the need for sensing chemicals in environmental monitoring, pollution control, modeling, medical diagnostics, and liquid sensing. It focuses on optical-based systems that are sensitive and selective, with an emphasis on portability and low power consumption. The approach involves addressing the vibrational modes of chemicals using laser beams to detect absorption frequencies, which can vary based on the chemical or isotopic nature of the molecules.