Receptors and Targeting

This lecture covers the fundamental concepts of receptors, including their structure, function, and communication through ligand-receptor binding. It explores the different types of receptors, such as G protein-coupled receptors and receptor tyrosine kinases, and their role in signal transduction. The lecture also delves into the classification of ligands, binding modes, binding strength, and the distinction between agonists and antagonists. Furthermore, it discusses the activation of the immune system through pattern recognition receptors and toll-like receptors. The importance of multivalency in receptor-ligand interactions is highlighted, along with examples of mono and multivalent receptors like ion channels and integrins in focal adhesions.