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This lecture delves into the advanced manufacturing of metals, focusing on the thermal history and microstructure of laser powder bed fusion (LPBF) processes. Dr. Charlotte de Formanoir discusses the epitaxial growth, solidification microstructure at grain and sub-grain levels, and the impact of process parameters on melt pool morphology. The lecture also covers the origin of porosity, keyhole mode formation, and lack-of-fusion defects. Strategies to mitigate residual stresses, enhance surface roughness, and optimize mechanical properties through post-treatments are explored. The importance of heat treatments in achieving balanced mechanical properties and the mechanical anisotropy of LPBF metals are highlighted. The lecture concludes by emphasizing the critical role of material science in additive manufacturing of metals.