Vision Restoration: Optogenetic Therapy & Retinal Prosthetics

This lecture delves into the cutting-edge research of Prof Serge Picaud on vision restoration through optogenetic therapy and retinal prosthetics. Prof Picaud explores the use of retinal implants and optogenetics to reactivate residual neurons in blind individuals, aiming to restore visual perception. The lecture covers the development of innovative implants, such as those combining stimulating electrodes and photodiodes, to trigger retinal ganglion cell responses. The discussion extends to the use of optogenetic proteins to make dormant cones photosensitive, potentially reactivating the retina. Prof Picaud also addresses the challenges of tissue remodeling and the need for high-resolution visual stimulation. The lecture concludes with insights into ongoing clinical trials and the future prospects of combining computer vision with implant technology.