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This lecture discusses the challenges faced by mobile terminals due to the increasing complexity surpassing battery capacity, emphasizing the importance of energy efficiency. It explores the optimization goals for future wireless multimedia terminals, focusing on energy efficiency, flexibility, and design productivity. The lecture also covers the design aspects of RF Frontend, physical layer processing, and algorithmic design. Additionally, it delves into the necessity of a new system theory for cognitive wireless networks and radios, leveraging semiconductor technology, machine learning, and networked system theory. The instructor highlights the importance of interdisciplinary research in solving complex problems and the critical assessment of outsourcing R&D. The lecture concludes by emphasizing the role of electrical engineering in addressing societal challenges and the need for universities to actively contribute to research clusters and prototype systems.