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This lecture covers the health effects of artificial light on living organisms, focusing on the mechanisms of light absorption and its impact on the human body, particularly the skin and eyes. It discusses the types of light, penetration through the skin and eye, and the potential adverse effects of different light wavelengths. Additionally, it explores the principles of fluorescence guided surgery, including the use of fluorophores like Indocyanine Green, mechanisms of fluorescence, and the application of imaging photoplethysmography in monitoring blood volume changes. The presentation also delves into the history and mechanisms of bright light therapy for psychiatric disorders, emphasizing the circadian rhythm, primary hormones, and the treatment of conditions such as seasonal affective disorder and depression.