Mechanism of Loop Diuretics

This lecture covers the mechanism of loop diuretics, focusing on the paracellular passage of ions in the renal tubule, the action of diuretics like furosemide and ethacrynic acid, and the importance of the wide ascending handle. It also discusses the mode of action of thiazides and potassium-sparing diuretics, including their effects on electrolyte reabsorption and excretion. Additionally, it explores the impact of different diuretics on various physiological processes, such as lipid metabolism, electrolyte balance, and renal function.