Diagnostic Tests: Sensitivity and Specificity

In course

Description

This lecture covers the concepts of Sensitivity and Specificity in diagnostic tests with binary classification outputs, such as pregnancy tests and biomarker tests. Sensitivity is the probability of providing a correct answer for positive samples, while Specificity is for negative samples. The lecture explains how these parameters depend on the biomarker measured and the threshold concentration chosen. It also introduces the Receiver Operating Characteristic (ROC) curve, which is used to compare diagnostic tests based on sensitivity and specificity. The importance of Precision in determining the probability of having a disease given a positive test result is also discussed, considering the prevalence of the disease in the population.

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Related lectures (32)

Related concepts (14)

Positive and negative predictive values

The positive and negative predictive values (PPV and NPV respectively) are the proportions of positive and negative results in statistics and diagnostic tests that are true positive and true negative results, respectively. The PPV and NPV describe the performance of a diagnostic test or other statistical measure. A high result can be interpreted as indicating the accuracy of such a statistic. The PPV and NPV are not intrinsic to the test (as true positive rate and true negative rate are); they depend also on the prevalence.

Sensitivity and specificity

Sensitivity and specificity mathematically describe the accuracy of a test that reports the presence or absence of a condition. If individuals who have the condition are considered "positive" and those who do not are considered "negative", then sensitivity is a measure of how well a test can identify true positives and specificity is a measure of how well a test can identify true negatives: Sensitivity (true positive rate) is the probability of a positive test result, conditioned on the individual truly being positive.

False positives and false negatives

A false positive is an error in binary classification in which a test result incorrectly indicates the presence of a condition (such as a disease when the disease is not present), while a false negative is the opposite error, where the test result incorrectly indicates the absence of a condition when it is actually present. These are the two kinds of errors in a binary test, in contrast to the two kinds of correct result (a and a ).

Accuracy and precision

Accuracy and precision are two measures of observational error. Accuracy is how close a given set of measurements (observations or readings) are to their true value, while precision is how close the measurements are to each other. In other words, precision is a description of random errors, a measure of statistical variability. Accuracy has two definitions: More commonly, it is a description of only systematic errors, a measure of statistical bias of a given measure of central tendency; low accuracy causes a difference between a result and a true value; ISO calls this trueness.

False alarm

A false alarm, also called a nuisance alarm, is the deceptive or erroneous report of an emergency, causing unnecessary panic and/or bringing resources (such as emergency services) to a place where they are not needed. False alarms may occur with residential burglary alarms, smoke detectors, industrial alarms, and in signal detection theory. False alarms have the potential to divert emergency responders away from legitimate emergencies, which could ultimately lead to loss of life.