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This lecture covers the energy resolution of detectors, the behavior of detectors in terms of sensitivity, linearity, and operational range, as well as the detection of unwanted contributions like background and selectivity. It also discusses dead time in detection, distinguishing between paralyzable and non-paralyzable dead time, and provides examples of their behavior. The lecture further explores the creation of electron-ion pairs, energy loss of particles, drift and collection of charges, and the detection regions in gas detectors, explaining the different regions based on the applied voltage. Various operation modes in detection are also discussed.