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This lecture covers the biological and molecular catalysts involved in the oxygen evolution reaction, a crucial step in water splitting for hydrogen production. It discusses the role of photosystem II in photosynthesis, the structure of the active site, and the challenges in O-O bond formation. The lecture also explores the use of molecular compounds, such as ruthenium complexes, as catalysts for oxygen evolution, highlighting their mechanisms and efficiency compared to chemical catalysis. The comparison of different catalysts and their rates provides insights into the development of efficient oxygen evolution catalysts.