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This lecture focuses on Implementation Research in the context of achieving and sustaining high ivermectin treatment coverage for diseases of poverty. It covers the evolution of Community-Directed Treatment, the main conclusions of multi-country studies, and the effectiveness and efficiency of the CDI process. The lecture also discusses the conceptual framework of the CDI process, critical factors facilitating CDI, and the reporting of research findings. Through examples and results from multi-country studies, the instructor illustrates how Implementation Research can significantly contribute to the effective delivery of health interventions for millions of people.