Sangram Shivdas Kale

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Sangram Shivdas Kale

Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

Cyclization of peptides with two chemical bridges affords large scaffold diversities

Cyclization of peptides with two chemical bridges affords large scaffold diversities

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries