A Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridine

A novel three-component synthesis of 5-aminooxazoles is reported. Its subsequent reaction with alpha ,beta -unsatd. acyl chloride leads to polysubstituted pyrrolopyridines. A triple domino process, acylation/IMDA/retro-Michael cycloreversion, was involved in the latter process. The methodol. allows the quick prepn., from simple and readily available inputs, of highly functionalized title compds. not easily accessed by other methods. [on SciFinder (R)]