An asymmetric total synthesis of sanjoinine G1

A convergent total synthesis of sanjoinine G1 (I), a 14-membered cyclopeptide alkaloid was described. Formation of aryl alkyl ether bond with concomitant construction of macrocycle by way of an intramol. SNAr reaction was the key step in this synthesis. Only two conventional peptide coupling steps were required for the prepn. of the cyclization precursor. [on SciFinder (R)]