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Publication
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The present invention concerns a new pharmaceutical composition comprising an antagonist and a co-agonist of the N-methyl-D-aspartate-type glutamate receptor (NMDAR). The inventors found that the co-administration of these two compounds effectively inhibits production of amyloide-² peptide. In patient's suffering from Alzheimer's disease, these peptides are deposited in the extracellular matrix forming neuritic "plaques". Therefore, the present inventors identified a new possibility for prophylaxis and/or treatment of Alzheimer's disease by stopping the continued formation of neuropathological extracellular deposits.
Pierre Magistretti, Igor Allaman, Pierre Marquet, Pascal Jourdain, Kaspar Rothenfusser
Maria del Carmen Sandi Perez, Graham Knott, Johannes Gräff, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Elias Georges Gebara, Jose Vicente Sanchez Mut, Catherine Maclachlan, Wei Tang, Bianca Ambrogina Silva, Alexandre Claude Gustave Bacq