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A case of Mycobacterium leprae rifampin resistance after irregular antile- prosy treatments since 1971 is reported. Whole-genome sequencing from four longi- tudinal samples indicated relapse due to acquired rifampin resistance and not to re- infection with another strain. A putative compensatory mutation in rpoC was also detected. Clinical improvement was achieved using an alternative therapy.
Bart Deplancke, Vincent Roland Julien Gardeux, Riccardo Dainese, Daniel Alpern
Tamar Kohn, Xavier Fernandez Cassi, Timothy R. Julian