Publication

On the similarity between aortic and carotid pressure diastolic decay: a mathematical modelling study

Résumé

Aortic diastolic pressure decay (DPD) has been shown to have considerable pathophysiological relevance in the assessment of vascular health, as it is significantly affected by arterial stiffening. Nonetheless, the aortic pressure waveform is rarely available and hence the utility of the aortic DPD is limited. On the other hand, carotid blood pressure is often used as a surrogate of central (aortic) blood pressure in cardiovascular monitoring. Although the two waveforms are inherently different, it is unknown whether the aortic DPD shares a common pattern with the carotid DPD. In this study, we compared the DPD time constant of the aorta (aortic RC) and the DPD time constant of the carotid artery (carotid RC) using an in-silico-generated healthy population from a previously validated onedimensional numerical model of the arterial tree. Our results demonstrated that there is near-absolute agreement between the aortic RC and the carotid RC. In particular, a correlation of similar to 1 was reported for a distribution of aortic/carotid RC values equal to 1.76 +/- 0.94 s/1.74 +/- 0.87 s. To the best of our knowledge, this is the first study to compare the DPD of the aortic and the carotid pressure waveform. The findings indicate a strong correlation between carotid DPD and aortic DPD, supported by the examination of curve shape and the diastolic decay time constant across a wide range of simulated cardiovascular conditions. Additional investigation is required to validate these results in human subjects and assess their applicability in vivo.

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Concepts associés (32)
Blood pressure
Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure" refers to the pressure in a brachial artery, where it is most commonly measured. Blood pressure is usually expressed in terms of the systolic pressure (maximum pressure during one heartbeat) over diastolic pressure (minimum pressure between two heartbeats) in the cardiac cycle.
Blood pressure measurement
Arterial blood pressure is most commonly measured via a sphygmomanometer, which historically used the height of a column of mercury to reflect the circulating pressure. Blood pressure values are generally reported in millimetres of mercury (mmHg), though aneroid and electronic devices do not contain mercury. For each heartbeat, blood pressure varies between systolic and diastolic pressures. Systolic pressure is peak pressure in the arteries, which occurs near the end of the cardiac cycle when the ventricles are contracting.
Artère carotide commune
vignette|Arc aortique avec ses collatérales. On observe les deux origines des artères carotides communes droite et gauche. En anatomie humaine, l'artère carotide commune (arteria carotis communis), ancienne artère carotide primitive, est une artère située dans le thorax et le cou, et qui vascularise la plus grande partie de la tête et une partie du cou. Dans le cou, elle a un trajet similaire à celui de la veine jugulaire interne et du nerf vague, au sein de la gaine carotidienne.
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Publications associées (38)

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