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The pancreas is an essential organ present in all vertebrates, and human pancreatic agenesis is an extremely rare disorder of largely unknown genetic determinants. A study now demonstrates that a primate-specific regulatory network controlled by the KRAB zinc-finger protein ZNF808 is essential for pancreas development.
Loïc Dayon, Andreas Wiederkehr, Sofia Moco, Isabelle Chareyron
Tobias Kober, Tom Hilbert, Reto Meuli, Josefina Adriana Maria Bastiaansen
Anne Grapin-Botton, Yung Hae Kim